If AD may correspond to spirochetoses, the microorganism should spread by hematogen dissemination; therefore the choroid plexus, which represents a barrier between blood and CSF, and several other organs than the brain may be affected. The results of extensive studies (Miklossy et al., 1998, 1999) showed that “curly fiber” and “tangle” formation is not unique to the central nervous system (CNS). Pathological fibrils with histochemical properties of amyloid, similar to neurofibrillary tangles and neuropil threads, associated with tau hyperphosphorylation, accumulate in the choroid plexus and various other organs than the brain. (Figure: Silver impregnated tangle-like structures in the adrenal.)