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1. Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC. Meningovascular form of neuroborreliosis: Similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. Acta Neuropathol 1990;80:568-572. http://www.springerlink.com/content/x7783gx742217207/fulltext.pdf


2. Kuntzer T, Bogousslavsky J, Miklossy J, Steck AJ, Janzer RC, Regli F. Borrelia rhombencephalomyelopathy. Arch Neurol 1991;48:832-836.

3 Miklossy J. Alzheimer's disease - A spirochetosis? NeuroReport 1993;4:841-848. Paper selected for press release.

4. Miklossy J. Kasas S, Janzer RC, Ardizzoni F, Van der Loos H. Further morphological evidence for a spirochetal etiology of Alzheimer's Disease. NeuroReport 1994; 5:1201-1204. IF : 2.374

5. Miklossy J. The spirochetal etiology of Alzheimer's disease: A putative therapeutic        approach. In: Alzheimer Disease: Therapeutic Strategies. Proceedings of the Third International Springfield Alzheimer Symposium. Giacobini E, Becker R  (Eds.) Birkhauser Boston Inc., 1994, Part I, pp.41-48.  

6. Miklossy J, Gern L, Darekar P, Janzer RC, Van der Loos H. Senile plaques, neurofibrillary tangles and neuropil threads contain DNA?  J. Spirochetal and  Tick-borne Diseases (JSTD), 1995;2:1-5.

7. Miklossy J, Darekar P, Gern L, Janzer RC, Bosman FT. Bacterial peptidoglycan in neuritic plaques in Alzheimer’s disease. Azheimer’s Res 1996;2: 95-100.

8. Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer's disease: Putative role of bacterial peptidoglycan, a potent inflammatory and amyloidogenic factor. Alzheimer's Rev 1998;3:45-51.

9. Miklossy J, Kraftsik R, Pillevuit O, Lepori D, Genton C, Bosman FT. Curly fiber and tangle-like inclusions in the ependyma and the choroid plexus - A pathogenetic relationship with the cortical Alzheimer-type changes? J Neuropathol Exp Neurol 1998;57:1202-1212.

10. Miklossy J, Taddei K, Martins R, Escher G, Kraftsik R, Pillevuit O, Lepori D, Campiche M Alzheimer’s disease: curly fibers and tangles in organs other than brain. J Neuropathol Exp Neurol 1999;58:803-814.

11. Suvà D, Favre I, Kraftsik R, Esteban M, Lobrinus A, Miklossy J. Involvement of primary motor cortex in Alzheimer’s disease. J Neuropathol Exp Neurol 1999;58:1125-1334.-                                                            
[Suvà D. “Involvement of the primary motor cortex in Alzheimer’s disease.” Doctoral thesis. University of Lausanne, Switzerland. 2001. (Director of the thesis: Miklossy J. Awarded by university prize)].

12. Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, H Hani E, Vionnet N, Nicod P, Boutin P, Froguel P. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nature Genetics 2000;24:291-295.

13. Mooser V, Helbecque N, Miklossy J, Marcovina SM, Nicod P, Amouyel Ph. Interactions between Apolipoprotein E and Apolipoprotein(a) in patients with Late-Onset Alzheimer disease. Ann Intern Med 2000;132:533-537.

14. Suter OC, Sunthorn T, Kraftsik R, Straubel J, Darekar P, Khalili K, Miklossy J.  Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease. Stroke 2002;33:1986-1992.

15. Helbecque N, Abderrhamani A, Meylan L, Riederer B, Mooser V, Miklossy J, Delplanque J, Boutin P, Nicod P, Haefliger J, Cottel D, Amouyel P, Froguel P, Waeber G. Islet-Brain 1/ C-Jun N-terminal Kinase Interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer’s disease. Molecular Psychiatry 2003;8:413-22.

16. Miklossy J. Taddei K, Suva D, Verdile G, Fonte J, Fisher C, Gnjec A, Ghika J, Suard Metha PD, McLean CA, Masters CL, Brooks WS, Martins RN. Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset  Alzheimer's disease. Neurobiol Aging 2003;24:655-662.

17. Miklossy J. Cerebral hypoperfusion induces cortical watershed microinfarcts which may further aggravate cognitive decline in Alzheimer's disease. Neurol Res (review).

18. Christen-Zaech S, Kraftsik R, Pillevuit O, Martins RN, Miklossy J. Early appearance of degenerative changes in the olfactory system in Alzheimer's disease. Can J Neurol Sci 2003;30:20-25. (Paper chosen for CME)

19. Miklossy J, Taddei K, Suva D, Verdile G, Fonte J, Fisher C, Gnjec A, Ghika J, Suard F, Mehta PD, McLean CA, Masters CL, Brooks WS, Martins RN. Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiol Aging. 2003;24:655-662.

20. Miklossy J, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster  BJ. Borrelia burgdorferi persists in the brain in chronic Lyme neuroborreliosis and may be associated with Alzheimer disease. J Alzheimer’s Dis 2004;6:639-649.

21. von Gunten A, Miklossy J, Suva ML, Hof PR, Giannakopoulos P. Environmental reduplicative paramnesia in a case of atypical Alzheimer's disease. Neurology 2004; 251:750-752.

22. Verdile G, Gnjec A, Miklossy J, Fonte J, Veurink G, Bates K, Kakulas B, Mehta PD, Milward EA, Tan N, Lareu R, Lim D, Dharmarajan A, Martins RN. Protein markers for Alzheimer disease in the frontal cortex and cerebellum. Neurology. 2004;63:1385-1392.


23. Miklossy J, Kis A, Radenovic A, Miller L, Forro L, Martins R, Reiss K, Darbinian N, Darekar P, Mihaly L, Khalili K. Beta amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. Neurobiol Aging 2006;27:228-236.

24.  Miller L.M., Wang AQ, Telivala TP, Randy J, , Smith RJ, Lanzirotti A., Miklossy J.    Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease. J Struct Biol. 2006;155:30-379. (Science Direct: between the 25 hottest articles, 2006)

25. Thesis. Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer`disease: the role of spirochetes

26. Arai T, Miklossy J, Klegeris A, Guo JP, McGeer PL. Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brain. J Neuropathol Exp Neurol. 2006;65:19-25.

27. Arai T, Akiyama H, J Miklossy, Guo JP, Klegeris A. Thrombin is a brain protease that processes tau. Neuropathology, 2006; 26:A8.

28. Miklossy J, Rosemberg S, McGeer PL. Beta amyloid deposition in the atrophic form of general paresis. In: Alzheimer’s Disease: New advances. Eds: Iqbal K, Winblad B, J Avila. Medimond. Intyernational Proceedings. Proceedings of the 10th International Congress on Alzheimer’s Disease (ICAD) 2006; pp. 429-433.  

29. Guo J, Arai T, Miklossy J, and McGeer PL. A-beta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer disease. P.N.A.S. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1953-1958. Epub 2006 Jan 30. Press release

30.  Miklossy J. Biology and neuropathology of dementia in syphilis and Lymedisease. In Handbook of Clinical Neurology, Vol 89 (3rd series) C Duyckaerts, I Litvan, Editors, 3008, Elsevier B.V. Handb Clin Neurol 2008; 89:825-844

31. Hashioka S, Miklossy J, Schwab S, Klegeris A, McGeer PL. Adhesion of exogenous human microglia and THP-1 cells to amyloid plaques of postmortem  Alzheimer’s disease brain. J Alzheimer Dis 2008; 14: 345-352

32. Darbinian N, Cui J,  Basile A, Del Valle L, Miklossy J, Sawaya BE, Amini S, Khalili K, and Gordon J. Negative regulation of AbPP gene expression by Pur-alpha. J Alzheimer’s Dis 2008; 15: 71-82

33. Gnjec A, D'Costa KJ, Laws SM, Hedley R, Balakrishnan K, Taddei K, Martins G, Paton A, Verdile G, Gandy SE, Broe GA, Brooks WS, Bennett H, Piguet O, Price P, Miklossy J, Hallmayer J, McGeer PL, Martins RN. Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. J Neuroinflammation. 2008; 5:36.

34. Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer's disease – role of spirochetes. J. Alzheimer’s Dis. 2008;13:381-391

 35. Weinberg ED, Miklossy J. Iron withholding: a defense against disease. Alzheimer’s Dis. 2008;13: (in press). http://www.j-alz.com/issues/13/vol13-4.html

36. Miklossy J, Martins RN, Darbinian N, Khalili K, McGeer PL. Type 2 diabetes: Local inflammation and direct effect of bacterial toxic products. Open Pathol J, 2008, 2: 86-95

37. Miklossy J, Kasas S, Zurn A, McCall S, Yu S, McGeer PL. Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. J. Neuroinflammation. 2008, 5:40

38. Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Làszló F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F, Khalili K, Darbinian-Sarlissian N, McGeer PL. Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging. 2010;31:1503-1515, PMID: 18950899

Miklossy J. Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria. J Neuroinflammation. 2011 Aug 4;8:90. http://www.jneuroinflammation.com/content/8/1/90

Miklossy J. Emerging roles of pathogens in Alzheimer disease. Expert Rev Mol Med. 2011 ; 13: e30 

Miklossy J. Chronic or late Lyme neuroborreliosis: Analysis of the evidence compared to chronic or late neurosyphilis. Open J Neurology  http://www.benthamscience.com/open/toneuj/articles/V006/SI0078TONEUJ/78TONEUJ.pdf  http://www.benthamscience.com/open/toneuj/articles/V006/SI0078TONEUJ/146TONEUJ.pdf







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