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EDUCATION

1965-1971          MD, University Medical School Debrecen, Hungary, EU&CH Conform Certif.
1971-1976          FRCP (H), Neurology, University of Debrecen (DOTE), EU, CH  Conform Certif.  1976-1982          FRCP (H) Psychiatry, National Inst. Neurol. & Psych.,  EU, CH Conform Certif.
1995                    Privatdozent (PD, Dr. habil., DSc), University of Lausanne, Switzerland                1995                    MER: University of Lausanne, Switzerland
2005                    PhD: University Medical School of Debrecen (DOTE)                        2009                    FRCP (CH) Neuropathology, University Medical School, Lausanne, Switzerland    2010                    President of the international Prevention Alzheimer Foundation, Switzerland  2010                    Director, Alzheimer Research Center, Switzerland                          


ACADEMIC AND CLINICAL APPOINTMENTS 
                       
1967-1971         Resident, Inst. Physiology, University Medical School of Debrecen, DOTE (H)  1971-1976         Resident, Inst. of Neurology, Psychiatry and Neurosurgery, DOTE University (H)   1977-1982         Staff member - Instructor, National Institute of Neurology and Psychiatry (H)
1982-2005         Staff member – Instructor,  University Inst. of Pathology, Lausanne, Switzerland    1995-                 MER, PD (Privatdozent, Dr. habil., D.Sc), equivalent of Assistant Professor,                                    CHUV & University of Lausanne, Switzerland                                                             1995-                 Head of Research group: Neurodegeneration, Univ. Inst. Pathology, Lausanne, CH 2001-2004         Molecular biology res., Center for NeuroVirology, Temple University, Philadelphia 2004 – 2007      Visiting scientist, head of neuropathology, Kinsmen Laboratory of  Neurological                              Research, University of   British  Columbia,  Vancouver, Canada                            2010 -                President of Prevention Alzheimer International Foundation and Director of                             International  Alzheimer Research Center, Switzerland


AWARDS AND HONORS                       

 1971     2nd national prize and 1st university prize of distinction for doctoral thesis  

 1975     Specialty Board Exam and Certificate in Neurology FRCP (EU&CH conform), with                distinction 5/5, Institute of Neurology, Psychiatry and Neurosurgery, DOTE, Hungary     

1976      Best young researcher award, Institute of Neurology, Psychiatry and Neurosurgery,                DOTE, University of Debrecen, Hungary 

 1980     Specialty Board Exam and Certificate in Psychiatry, FRCP (H), with distinction 5/5,                             National Institute of Neurology and Psychiatry, OIEI, Hungary.

1995      P.D and M.ER (Dr. habil, DSc) – equivalent of Assistant Professor, University Institute of               Pathology,  University of Lausanne, Switzerland 

2005      PhD degree, Summa cum laude, University Medical School of Debrecen, Hungary

2005-    On the scientific Advisory Board of  Canadian Lyme Foundation                                     2008-    On the scientific advisory Board of Deutsche Borreliose Gesellschaft                              1985-    Member of various international and national neuroscience, neuropathology and               neurology associations and organizations                                                                            1995-    Member of the Association of Director Physicians of Swiss Hospitals; Verein der               Spitalarzte des Schweiz (VLSS); Association des Medecins Dirigeants               d'Hopitaux de Suisse  (AMDHS)        




PUBLICATIONS

Number of publications (articles, book chapters and published abstracts: 238)

Published articles and book chapters: 111 (104 per reviewed)

Mean impact factor: 5.02

SELECTED REFERENCES

1. Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC. Meningovascular form of neuroborreliosis: Similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. Acta Neuropathol 1990;80:568-572.

2. Miklossy J. Alzheimer's disease - A spirochetosis? Neuroreport. 1993; 4:841-848. Press release.

3. Miklossy J, Van der Loos H. The long distance effects of brain lesions: A study of myelinated pathways in the human brain using polarizing and fluorescence microscopy. J Neuropathol Exp Neurol 1991;50:1-15. 

4. Miklossy J, Taddei K, Martins R, Escher G, Kraftsik R, Pillevuit O, Lepori D, Campiche M. Alzheimer disease: curly fibers and tangles in organs other than brain. J Neuropathol Exp Neurol. 1999;58:803-814. 

 5. Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, H Hani E, Vionnet N, Nicod P, Boutin P, Froguel P. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nature Genetics 2000;24:291-295. Press release.

 6. Mooser V, Helbecque N, Miklossy J, Marcovina SM, Nicod P, Amouyel Ph. Interactions between Apolipoprotein E and Apolipoprotein(a) in patients with Late-Onset Alzheimer disease. Ann Intern Med 2000;132:533-537. Press release. 

7. Miklossy J, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ. Borrelia burgdorferi persists in the brain in chronic Lyme neuroborreliosis and may be associated with Alzheimer disease. J Alzheimer’s Dissease 2004, 6 (6): 1-11. 

8. Helbecque N, Abderrhamani A, Meylan L, Riederer B, Mooser V, Miklossy J, Delplanque J, Boutin P, Nicod P, Haefliger J, Cottel D, Amouyel P, Froguel P, Waeber G. Islet-Brain 1/ C-Jun N-terminal Kinase Interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer’s disease.  Molecular Psychiatry 2003;8:413-22. 

9. Miklossy J, Taddei K, Suva D, Verdile G, Fonte J, Fischer C, Gnjec A, Ghika J, Suard F, Mehta PD, McLean CA, Masters CL, Brooks WS, Martins RN. Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiol Aging. 2003;24:655-662.

10. Guo J, Arai T, Miklossy J, and McGeer PL. A-beta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer disease. Proc Natl Acad Sci U S A. 2006 ;103:1953-8. Press release.

11. Miklossy J, Kis A, Radenovic A, Miller L, Forro L, Martins RN, Reiss K, Darbinian N, Darekar P, Mihaly L, Khalili K. Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. Neurobiol Aging 2006;27:228-236. 

13. Miklossy J. Biology and neuropathology of dementia in syphilis and Lyme disease. In Handbook of Clinical Neurology, Vol 89 (3rd series) C Duyckaerts, I Litvan, Editors, 3008, Elsevier B.V. Chapter of Handbook of Neurology Handbook of Clinical Neurology, 2008; 89: 825-844.

Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer's disease – role of spirochetes. J. Alzheimer’s Dis. 2008;13: 381.391. http://www.j-alz.com/issues/13/vol13-4.html

15. Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Làszló F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F, Khalili K, Darbinian-Sarlissian N, McGeer PL. Beta amyloid and hyper-phosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging. 2010, 31:1503-1511.

16. Miklossy J, Kasas S, Zurn A, McCall S, Yu S, McGeer PL. Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. J. Neuroinflammation. 2008, 5:40

17. Miklossy J, Martins RN, Darbinian N, Khalili K, McGeer PL. Type 2 diabetes: Local inflammation and direct effect of bacterial toxic products. Open Pathol J, 2008, 2: 86-95



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