EDUCATION

1965-1971            M.D., University Medical School, DOTE, Debrecen, Hungary  
1971-1976            F.R.C.P. (H) Neurology, DOTE, Inst. Neurology, Hungarian Academy of Sciences
1976-1982            F.R.C.P. (H) Psychiatry, OIEI, Budapest, Hungarian Academy of Science
1982-2005            P.D., M.E.R., Neuropathol., IUPA, CHUV, University of Lausanne, Switzerland
2005                     Ph.D., University of Debrecen, Hungary and UBC, Vancouver, Canada
                                        

ACADEMIC AND CLINICAL APPOINTMENTS 
                       
1967-1971       Resident, Institute of Physiology, DOTE, Debrecen, Hungary

1971-1976       Resident, Chief-Resident, staff member, neurologist, Institute of Neurology, Psychiatry and Neurosurgery, DOTE, Debrecen, Hungary

1977-1982       Staff member - Instructor, psychiatrist, National Institute of Neurology and Psychiatry, OIEI, Budapest, Hungary

1982-1995       Staff member – Instructor, neuropathologist, University Medical School of Lausanne, Switzerland  

1995-2005       Staff member, Medecin associe, MER, PD, equivalent Assistant Professor, University Institute of Pathology, CHUV, University Medical School of Lausanne

1995-               Head of the Research group "Neurodegeneration" University Institute of Pathology, CHUV, University Medical School of Lausanne

2001-2004       Molecular biology research in neuroscience as visiting scientist, Center for NeuroVirology, Temple University, Philadelphia, PA, USA

2004 – 2007     Neuroscience research as visiting scientist, Kinsmen Laboratory of Neurological Research, The British Columbia University, Vancouver, BC, Canada

AWARDS AND HONORS                       

 1971     M. D. degree University Medical School of Debrecen, Hungary. 2nd national and 1st                university prize of distinction for M.D. thesis
1975     Specialty board Exam and Certificate in Neurology F.R.C.P. (H), with mention (5/5)               Institute of Neurology, Psychiatry and Neurosurgery, DOTE                                          1976     Best young researcher award, Institute of Neurology, Psychiatry and Neurosurgery,               DOTE, University of Debrecen, Hungary
1980     Specialty board Exam and Certificate in Psychiatry, F.R.C.P. (H) with mention (5/5),                            National Institute of Neurology and Psychiatry, OIEI, Hungarian Academy of Sciences.
1995     P.D. and M.E.R. degrees – Assistant Professor, University Institute of Pathology,               Lausanne, Switzerland 
2005     Ph. D. degree, Summa cum laude, University Medical School of Debrecen, Hungary

 On the Board of directors of the Canadian Lyme Association                                                Advisory board member of the Deutsche Borreliose Gesellschaft
 Member of the Association of Director Physicians of Swiss Hospitals  [Verein der Leitenden Spitalarzte des Schweiz (VLSS) or Association des Medecins Dirigeants d'Hopitaux de Suisse (AMDHS)].
 Member of several international and national neuroscience, neuropathology and neurology associations and organisations.

SELECTED REFERENCES

1. Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC. Meningovascular form of neuroborreliosis: Similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. Acta Neuropathol 1990;80:568-572.

2. Miklossy J. Alzheimer's disease - A spirochetosis? Neuroreport. 1993; 4:841-848. Press release.

3. Miklossy J, Van der Loos H. The long distance effects of brain lesions: A study of myelinated pathways in the human brain using polarizing and fluorescence microscopy. J Neuropathol Exp Neurol 1991;50:1-15. 

4. Miklossy J, Taddei K, Martins R, Escher G, Kraftsik R, Pillevuit O, Lepori D, Campiche M. Alzheimer disease: curly fibers and tangles in organs other than brain. J Neuropathol Exp Neurol. 1999;58:803-814. 

 5. Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, H Hani E, Vionnet N, Nicod P, Boutin P, Froguel P. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nature Genetics 2000;24:291-295. Press release.

 6. Mooser V, Helbecque N, Miklossy J, Marcovina SM, Nicod P, Amouyel Ph. Interactions between Apolipoprotein E and Apolipoprotein(a) in patients with Late-Onset Alzheimer disease. Ann Intern Med 2000;132:533-537. Press release. 

7. Miklossy J, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ. Borrelia burgdorferi persists in the brain in chronic Lyme neuroborreliosis and may be associated with Alzheimer disease. J Alzheimer’s Dissease 2004, 6 (6): 1-11. 

8. Helbecque N, Abderrhamani A, Meylan L, Riederer B, Mooser V, Miklossy J, Delplanque J, Boutin P, Nicod P, Haefliger J, Cottel D, Amouyel P, Froguel P, Waeber G. Islet-Brain 1/ C-Jun N-terminal Kinase Interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer’s disease.  Molecular Psychiatry 2003;8:413-22. 

9. Miklossy J, Taddei K, Suva D, Verdile G, Fonte J, Fischer C, Gnjec A, Ghika J, Suard F, Mehta PD, McLean CA, Masters CL, Brooks WS, Martins RN. Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiol Aging. 2003;24:655-662.

10. Guo J, Arai T, Miklossy J, and McGeer PL. A-beta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer disease. P.N.A.S. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1953-8. Press release.

11. Miklossy J, Kis A, Radenovic A, Miller L, Forro L, Martins RN, Reiss K, Darbinian N, Darekar P, Mihaly L, Khalili K. Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes.  Neurobiol Aging 2006;27:228-236. 

12. Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer`disease: the role of spirochetes. Thesis.

13. Miklossy J. Biology and neuropathology of dementia in syphilis and Lymedisease. In Handbook of Clinical Neurology, Vol 89 (3rd series) C Duyckaerts, I Litvan, Editors, 3008, Elsevier B.V. Chapter of Handbook of Neurology (in press)

14. Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer's disease – role of spirochetes. J. Alzheimer’s Dis. 2008;13: (in press). http://www.j-alz.com/issues/13/vol13-4.html

15. Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Làszló F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F, Khalili K, Darbinian-Sarlissian N, McGeer PL. Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging. 2008, Oct 16, PMID: 18950899

16. Miklossy J, Kasas S, Zurn A, McCall S, Yu S, McGeer PL. Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. J. Neuroinflammation. 2008, 5:40

17. Miklossy J, Martins RN, Darbinian N, Khalili K, McGeer PL. Type 2 diabetes: Local inflammation and direct effect of bacterial toxic products. Open Pathol J, 2008, 2: 86-95