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EDUCATION

1971                MD, University Medical School of Debrecen, Hungary 

 1971-1976       FRCP (H, EU conform) - Board certified in Neurology, University Medical School of Debrecen, Hungary

1976-1982       FRCP (H, EU conform) Board certified in Psychiatry and Psychotherapy, National Institute of Neurology and Psychiatry, Budapest, Hungary

1982-2005      PD (Dr. habil. or DSc) and MER, Neuropathology, University Institute of                           Pathology, CHUV, University of Lausanne, Switzerland

2005                PhD, University Medical School of Debrecen, (DOTE), Director of thesis PL McGeer, University of British Columbia, Vancouver, Canada

2010                FRCP (FMH, EU conform) Board certified in Neuropathology, Fédération des                                Médecins suisses, Switzerland           

                               

ACADEMIC AND CLINICAL APPOINTMENTS 

1967-1971      Resident, Neurobiology research, Institute of Physiology, DOTE, Debrecen,                                   Hungary

1971-1976       Resident, Instructor, neurologist, Institute of Neurology, Psychiatry and Neurosurgery, DOTE, Debrecen, Hungary

1977-1982      Instructor, Staff member, Psychiatry, National Institute of Neurology and                           Psychiatry, OIEI, Budapest, Hungary

1982-2005       Neuropathology, Médecin associé, Staff member, University Medical School of Lausanne, Switzerland                           

1995-               Head of “Neurodegeneration” research group. University Institute of Pathology

1995                           PD (Dr. habil. or DSc), MER (assistant professor) CHUV, UNIL, Lausanne, Switzerland 

2001-2004      Molecular biology, Center for NeuroVirology, Temple University, Philadelphia,                             PA, USA

2004 – 2006    Neurological research, Kinsmen Laboratory of Neurological Research, The                        British Columbia University, Vancouver, BC, Canada     

2010                Director of International Alzheimer Research Center of Prevention Alzheimer International Foundation, Switzerland

 

AWARDS AND HONORS                   

1971                MD degree (cum laude) University Medical School of Debrecen, Hungary: Second national and first university prize of distinction for doctoral thesis.

1975                Specialty board Exam and Certificate in Neurology with distinction 5/5

1976                Best young researcher award, Institute of Neurology, Psychiatry and Neurosurgery, DOTE, University of Debrecen, Hungary

1980                Specialty board Exam and Certificate in Psychiatry, FRCP with distinction 5/5

1995                PD (DSc or Dr habil.) and MER – (equivalent assistant professor), University Institute of Pathology, Lausanne, Switzerland 

2005                PhD degree, (summa cum laude), University Medical School of Debrecen, Hungary

 

Member of various scientific organizations and associations related to neuroscience.
Member of Director Physicians of Swiss Hospitals
2005- 2012 On the Board of Directors and from 2009-2012 scientific advisor of the Canadian Lyme Association, 2007- On the Scientific Advisory Board of German Borreliosis Society (Borreliose-Gesellschaft, Germany), On the Board of scientific advisory panel of Lyme Research Alliance in partnership with Columbia University Medical Center in New York City.

 



PUBLICATIONS

Number of publications (articles, book chapters and published abstracts: 238)

Published articles and book chapters: 111 (104 per reviewed)

Mean impact factor: 5.02


SELECTED REFERENCES

1. Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC. Meningovascular form of neuroborreliosis: Similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. Acta Neuropathol 1990;80:568-572.

2. Miklossy J. Alzheimer's disease - A spirochetosis? Neuroreport. 1993; 4:841-848. Press release.

3. Miklossy J, Van der Loos H. The long distance effects of brain lesions: A study of myelinated pathways in the human brain using polarizing and fluorescence microscopy. J Neuropathol Exp Neurol 1991;50:1-15. 

4. Miklossy J, Taddei K, Martins R, Escher G, Kraftsik R, Pillevuit O, Lepori D, Campiche M. Alzheimer disease: curly fibers and tangles in organs other than brain. J Neuropathol Exp Neurol. 1999;58:803-814. 

 5. Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, H Hani E, Vionnet N, Nicod P, Boutin P, Froguel P. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nature Genetics 2000;24:291-295. Press release.

 6. Mooser V, Helbecque N, Miklossy J, Marcovina SM, Nicod P, Amouyel Ph. Interactions between Apolipoprotein E and Apolipoprotein(a) in patients with Late-Onset Alzheimer disease. Ann Intern Med 2000;132:533-537. Press release. 

7. Miklossy J, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ. Borrelia burgdorferi persists in the brain in chronic Lyme neuroborreliosis and may be associated with Alzheimer disease. J Alzheimer’s Dissease 2004, 6 (6): 1-11. 

8. Helbecque N, Abderrhamani A, Meylan L, Riederer B, Mooser V, Miklossy J, Delplanque J, Boutin P, Nicod P, Haefliger J, Cottel D, Amouyel P, Froguel P, Waeber G. Islet-Brain 1/ C-Jun N-terminal Kinase Interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer’s disease.  Molecular Psychiatry 2003;8:413-22. 

9. Miklossy J, Taddei K, Suva D, Verdile G, Fonte J, Fischer C, Gnjec A, Ghika J, Suard F, Mehta PD, McLean CA, Masters CL, Brooks WS, Martins RN. Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiol Aging. 2003;24:655-662.

10. Guo J, Arai T, Miklossy J, and McGeer PL. A-beta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer disease. Proc Natl Acad Sci U S A. 2006 ;103:1953-8. Press release.

11. Miklossy J, Kis A, Radenovic A, Miller L, Forro L, Martins RN, Reiss K, Darbinian N, Darekar P, Mihaly L, Khalili K. Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. Neurobiol Aging 2006;27:228-236. 

13. Miklossy J. Biology and neuropathology of dementia in syphilis and Lyme disease. In Handbook of Clinical Neurology, Vol 89 (3rd series) C Duyckaerts, I Litvan, Editors, 3008, Elsevier B.V. Chapter of Handbook of Neurology Handbook of Clinical Neurology, 2008; 89: 825-844.

Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer's disease – role of spirochetes. J. Alzheimer’s Dis. 2008;13: 381.391. http://www.j-alz.com/issues/13/vol13-4.html

15. Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Làszló F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F, Khalili K, Darbinian-Sarlissian N, McGeer PL. Beta amyloid and hyper-phosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging. 2010, 31:1503-1511.

16. Miklossy J, Kasas S, Zurn A, McCall S, Yu S, McGeer PL. Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. J. Neuroinflammation. 2008, 5:40

17. Miklossy J, Martins RN, Darbinian N, Khalili K, McGeer PL. Type 2 diabetes: Local inflammation and direct effect of bacterial toxic products. Open Pathol J, 2008, 2: 86-95

18. Miklossy J. Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria. J Neuroinflammation. 2011 Aug 4;8:90. http://www.jneuroinflammation.com/content/8/1/90

10. Miklossy J. Emerging roles of pathogens in Alzheimer disease. Expert Rev Mol Med. 2011 ; 13: e30 

20. Miklossy J. Chronic or late Lyme neuroborreliosis: Analysis of the evidence compared to chronic or late neurosyphilis. Open J Neurology  http://www.benthamscience.com/open/toneuj/articles/V006/SI0078TONEUJ/78TONEUJ.pdf  http://www.benthamscience.com/open/toneuj/articles/V006/SI0078TONEUJ/146TONEUJ.pdf


 



 






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