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EDUCATION
1965-1971 MD, University Medical School Debrecen, Hungary, EU&CH Conform Certif.
1971-1976 FRCP (H), Neurology, University of Debrecen (DOTE), EU, CH Conform Certif. 1976-1982 FRCP (H) Psychiatry, National Inst. Neurol. & Psych., EU, CH Conform Certif.
1995 Privatdozent (PD, Dr. habil., DSc), University of Lausanne, Switzerland 1995 MER: University of Lausanne, Switzerland
2005 PhD: University Medical School of Debrecen (DOTE) 2009 FRCP (CH) Neuropathology, University Medical School, Lausanne, Switzerland 2010 President of the international Prevention Alzheimer Foundation, Switzerland 2010 Director, Alzheimer Research Center, Switzerland
ACADEMIC AND CLINICAL APPOINTMENTS
1967-1971 Resident, Inst. Physiology, University Medical School of Debrecen, DOTE (H) 1971-1976 Resident, Inst. of Neurology, Psychiatry and Neurosurgery, DOTE University (H) 1977-1982 Staff member - Instructor, National Institute of Neurology and Psychiatry (H)
1982-2005 Staff member – Instructor, University Inst. of Pathology, Lausanne, Switzerland 1995- MER, PD (Privatdozent, Dr. habil., D.Sc), equivalent of Assistant Professor, CHUV & University of Lausanne, Switzerland 1995- Head of Research group: Neurodegeneration, Univ. Inst. Pathology, Lausanne, CH 2001-2004 Molecular biology res., Center for NeuroVirology, Temple University, Philadelphia 2004 – 2007 Visiting scientist, head of neuropathology, Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada 2010 - President of Prevention Alzheimer International Foundation and Director of International Alzheimer Research Center, Switzerland
AWARDS AND HONORS
1971 2nd national prize and 1st university prize of distinction for doctoral thesis
1975 Specialty Board Exam and Certificate in Neurology FRCP (EU&CH conform), with distinction 5/5, Institute of Neurology, Psychiatry and Neurosurgery, DOTE, Hungary
1976 Best young researcher award, Institute of Neurology, Psychiatry and Neurosurgery, DOTE, University of Debrecen, Hungary
1980 Specialty Board Exam and Certificate in Psychiatry, FRCP (H), with distinction 5/5, National Institute of Neurology and Psychiatry, OIEI, Hungary.
1995 P.D and M.ER (Dr. habil, DSc) – equivalent of Assistant Professor, University Institute of Pathology, University of Lausanne, Switzerland
2005 PhD degree, Summa cum laude, University Medical School of Debrecen, Hungary
2005- On the scientific Advisory Board of Canadian Lyme Foundation 2008- On the scientific advisory Board of Deutsche Borreliose Gesellschaft 1985- Member of various international and national neuroscience, neuropathology and neurology associations and organizations 1995- Member of the Association of Director Physicians of Swiss Hospitals; Verein der Spitalarzte des Schweiz (VLSS); Association des Medecins Dirigeants d'Hopitaux de Suisse (AMDHS)
PUBLICATIONS
Number of publications (articles, book chapters and published abstracts: 238)
Published articles and book chapters: 111 (104 per reviewed)
Mean impact factor: 5.02
SELECTED REFERENCES
1. Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC. Meningovascular form of neuroborreliosis: Similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. Acta Neuropathol 1990;80:568-572.
2. Miklossy J. Alzheimer's disease - A spirochetosis? Neuroreport. 1993; 4:841-848. Press release.
3. Miklossy J, Van der Loos H. The long distance effects of brain lesions: A study of myelinated pathways in the human brain using polarizing and fluorescence microscopy. J Neuropathol Exp Neurol 1991;50:1-15.
4. Miklossy J, Taddei K, Martins R, Escher G, Kraftsik R, Pillevuit O, Lepori D, Campiche M. Alzheimer disease: curly fibers and tangles in organs other than brain. J Neuropathol Exp Neurol. 1999;58:803-814.
5. Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, H Hani E, Vionnet N, Nicod P, Boutin P, Froguel P. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nature Genetics 2000;24:291-295. Press release.
6. Mooser V, Helbecque N, Miklossy J, Marcovina SM, Nicod P, Amouyel Ph. Interactions between Apolipoprotein E and Apolipoprotein(a) in patients with Late-Onset Alzheimer disease. Ann Intern Med 2000;132:533-537. Press release.
7. Miklossy J, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ. Borrelia burgdorferi persists in the brain in chronic Lyme neuroborreliosis and may be associated with Alzheimer disease. J Alzheimer’s Dissease 2004, 6 (6): 1-11.
8. Helbecque N, Abderrhamani A, Meylan L, Riederer B, Mooser V, Miklossy J, Delplanque J, Boutin P, Nicod P, Haefliger J, Cottel D, Amouyel P, Froguel P, Waeber G. Islet-Brain 1/ C-Jun N-terminal Kinase Interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer’s disease. Molecular Psychiatry 2003;8:413-22.
9. Miklossy J, Taddei K, Suva D, Verdile G, Fonte J, Fischer C, Gnjec A, Ghika J, Suard F, Mehta PD, McLean CA, Masters CL, Brooks WS, Martins RN. Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiol Aging. 2003;24:655-662.
10. Guo J, Arai T, Miklossy J, and McGeer PL. A-beta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer disease. Proc Natl Acad Sci U S A. 2006 ;103:1953-8. Press release.
11. Miklossy J, Kis A, Radenovic A, Miller L, Forro L, Martins RN, Reiss K, Darbinian N, Darekar P, Mihaly L, Khalili K. Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. Neurobiol Aging 2006;27:228-236.
13. Miklossy J. Biology and neuropathology of dementia in syphilis and Lyme disease. In Handbook of Clinical Neurology, Vol 89 (3rd series) C Duyckaerts, I Litvan, Editors, 3008, Elsevier B.V. Chapter of Handbook of Neurology Handbook of Clinical Neurology, 2008; 89: 825-844.
Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer's disease – role of spirochetes. J. Alzheimer’s Dis. 2008;13: 381.391. http://www.j-alz.com/issues/13/vol13-4.html
15. Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Làszló F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F, Khalili K, Darbinian-Sarlissian N, McGeer PL. Beta amyloid and hyper-phosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging. 2010, 31:1503-1511.
17. Miklossy J, Martins RN, Darbinian N, Khalili K, McGeer PL. Type 2 diabetes: Local inflammation and direct effect of bacterial toxic products. Open Pathol J, 2008, 2: 86-95
