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EDUCATION
1965-1971 M.D., University Medical School, DOTE, Debrecen, Hungary
1971-1976 F.R.C.P. (H) Neurology, DOTE, Inst. Neurology, Hungarian Academy of Sciences
1976-1982 F.R.C.P. (H) Psychiatry, OIEI, Budapest, Hungarian Academy of Science
1982-2005 P.D., M.E.R., Neuropathol., IUPA, CHUV, University of Lausanne, Switzerland
2005 Ph.D., UBC, Vancouver, Canada and University of Debrecen, Hungary
ACADEMIC AND CLINICAL APPOINTMENTS
Positions and employments
1967-1971 Resident, Institute of Physiology, DOTE, Debrecen, Hungary
1971-1976 Resident, Chief-Resident, staff member, neurologist, Institute of Neurology, Psychiatry and Neurosurgery, DOTE, Debrecen, Hungary
1977-1982 Staff member - Instructor, psychiatrist, National Institute of Neurology and Psychiatry, OIEI, Budapest, Hungary
1982-1995 Staff member – Instructor, neuropathologist, University Medical School of Lausanne, Switzerland
1995-2005 Staff member, Medecin associe, MER, PD, Assistant Professor, University Institute of Pathology, CHUV, University Medical School of Lausanne
1995- Head of the Research group "Neurodegeneration" University Institute of Pathology, CHUV, University Medical School of Lausanne
2001-2004 Molecular biology research in neuroscience as visiting scientist, Center for NeuroVirology, Temple University, Philadelphia, PA, USA
2004 – 2007 Neuroscience research as visiting scientist, Kinsmen Laboratory of Neurological Research, The British Columbia University, Vancouver, BC, Canada
AWARDS AND HONORS
1971 M. D. degree University Medical School of Debrecen, Hungary. 2nd national and 1st university prize of distinction for thesis
1975 Specialty board Exam and Certificate in Neurology F.R.C.P. (H), with mention (5/5) Institute of Neurology, Psychiatry and Neurosurgery, DOTE, Hungarian Academy of Sciences
1976 Best young researcher award, Institute of Neurology, Psychiatry and Neurosurgery, DOTE, University of Debrecen, Hungary
1980 Specialty board Exam and Certificate in Psychiatry, F.R.C.P. (H) with mention (5/5), National Institute of Neurology and Psychiatry, OIEI, Hungarian Academy of Sciences.
1995 P.D. and M.E.R. degrees – Assistant Professor, University Institute of Pathology, Lausanne, Switzerland
2005 Ph. D. degree, Summa cum laude, University Medical School of Debrecen, Academy of Sciences, Hungary.
Member of the Board of directors of the Canadian Lyme Association Advisory board member of the Deutsche Borreliose Gesellschaft
Member of the Association of Director Physicians of Swiss Hospitals [Verein der Leitenden Spitalarzte des Schweiz (VLSS) or Association des Medecins Dirigeants d'Hopitaux de Suisse (AMDHS)].
Member of several neuroscience, neuropathology and neurology associations and organisations.
SELECTED REFERENCES
1. Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC. Meningovascular form of neuroborreliosis: Similarities between neuropathological findings in a case of Lyme disease and those occurring in tertiary neurosyphilis. Acta Neuropathol 1990;80:568-572.
2. Miklossy J. Alzheimer's disease - A spirochetosis? Neuroreport. 1993; 4:841-848. Press release.
3. Miklossy J, Van der Loos H. The long distance effects of brain lesions: A study of myelinated pathways in the human brain using polarizing and fluorescence microscopy. J Neuropathol Exp Neurol 1991;50:1-15.
4. Miklossy J, Taddei K, Martins R, Escher G, Kraftsik R, Pillevuit O, Lepori D, Campiche M. Alzheimer disease: curly fibers and tangles in organs other than brain. J Neuropathol Exp Neurol. 1999;58:803-814.
5. Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, H Hani E, Vionnet N, Nicod P, Boutin P, Froguel P. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nature Genetics 2000;24:291-295. Press release.
6. Mooser V, Helbecque N, Miklossy J, Marcovina SM, Nicod P, Amouyel Ph. Interactions between Apolipoprotein E and Apolipoprotein(a) in patients with Late-Onset Alzheimer disease. Ann Intern Med 2000;132:533-537. Press release.
7. Miklossy J, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J, Paster BJ. Borrelia burgdorferi persists in the brain in chronic Lyme neuroborreliosis and may be associated with Alzheimer disease. J Alzheimer’s Dissease 2004, 6 (6): 1-11.
8. Helbecque N, Abderrhamani A, Meylan L, Riederer B, Mooser V, Miklossy J, Delplanque J, Boutin P, Nicod P, Haefliger J, Cottel D, Amouyel P, Froguel P, Waeber G. Islet-Brain 1/ C-Jun N-terminal Kinase Interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer’s disease. Molecular Psychiatry 2003;8:413-22.
9. Miklossy J, Taddei K, Suva D, Verdile G, Fonte J, Fischer C, Gnjec A, Ghika J, Suard F, Mehta PD, McLean CA, Masters CL, Brooks WS, Martins RN. Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiol Aging. 2003;24:655-662.
10. Guo J, Arai T, Miklossy J, and McGeer PL. A-beta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer disease. P.N.A.S. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1953-8. Press release.
11. Miklossy J, Kis A, Radenovic A, Miller L, Forro L, Martins RN, Reiss K, Darbinian N, Darekar P, Mihaly L, Khalili K. Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. Neurobiol Aging 2006;27:228-236.
12. Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer`disease: the role of spirochetes. Thesis.
13. Miklossy J. Biology and neuropathology of dementia in syphilis and Lymedisease. In Handbook of Clinical Neurology, Vol 89 (3rd series) C Duyckaerts, I Litvan, Editors, 3008, Elsevier B.V. Chapter of Handbook of Neurology (in press)
14. Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer's disease – role of spirochetes. J. Alzheimer’s Dis. 2008;13: (in press). http://www.j-alz.com/issues/13/vol13-4.html
