Bacterial peptidoglycan, a cell wall component of bacteria  (including spirochetes), is colocalized with senile plaques and neurofibrillary tangles in Alzheimer's disease
Bacterial peptidoglycan, the cell wall component of virtually all Eubacteria, including spirochetes, which is a potent stimulator of inflammation and amyloidosis had been detected immunohistochemically in senile plaques and neurofibrillary tangles of 17 AD cases analyzed and was absent in 7 control cases. In senile plaques bacterial peptidoglycan was co-localized with Aβ (Miklossy et al., 1996. Miklossy, 1998).